Endocrine Abstracts

Introduction: Thyroid storm is a rare endocrine emergency associated with the reported mortality rate ranging from 10 to 20%. We discussed the management of two cases of thyroid storm with different outcomes. It also showed the successful use of ECMO in the management of severe hyperthyroidism related cardiomyopathy and circulatory collapse.Case History 1: A 36 years old female with known history of Graves’ disease, presented with palpitations and s...

Introduction: UK NICE guidelines recommend that men with diabetes mellitus (DM) should be reviewed annually regarding symptoms of erectile dysfunction (ED) in view of possible phosphodiesterase-5 (PDE-5) inhibitor treatment. Previous studies have shown that 70% of men with ED have concomitant lower urinary tract symptoms (LUTS). It has been suggested that there may be some common patho-physiology accounting for the improvement in LUTS seen in men with ED and LUTS treated with ...

Introduction: Changing of expression of pattern-recognition receptors (PRR) of innate immune response by the gut-associated lymphoid tissue (GALT) can play a critical role in an induction and progression of T1DM.Aim: To study the peculiarities of NOD2 receptors in gut-associated lymphoid tissues (GALT) of rats with experimental STZ-induced diabetes mellitus and pentoxifylline (PTX) administration.Methods: Researches were made on Wi...

The basis of the pathogenesis of nonalcoholic fatty liver disease (NAFLD) is insulin resistance (IR) which appears on the background of abdominal obesity (AO) which, in turn, is a key factor in the emergence of an imbalance between adipocytokines entailing a disturbance of lipid and carbohydrate metabolism, which ultimately leads to the damage of the liver cells, the development of inflammation, fibrosis and apoptosis. The goal – to study features of changes in the level ...

Introduction: Peripheral diabetic neuropathic pain (PDNP) as a significant complication of diabetes mellitus (DM), which is present in 16–26% of patients. NICE UK guidelines recommend that physicians should make an formal enquiry about distressing neuropathic symptoms annually and that either duloxetine, amitriptyline, gabapentin, or pregabalin should be used as first-line treatment for neuropathic pain.Aims: To assess the prevalence PDNP in a diabe...

A 42-year-old man undergoing ipilimumab therapy for stage IV metastatic melanoma presented after his third dose with vomiting, abdominal pain, hypotension, and pyrexia. He was treated as a presumed line sepsis. Four days prior to admission, thyroid function test showed T4 of 7.9 pmol/l and TSH 0.02 mU/l and he was treated with levothyroxine. A pituitary profile was carried out on admission and the results were as follows, cortisol was 24 nmol/l, testosterone <0....

Introduction: I report the case of a premature neonate who developed a transient hyperphosphatemia at 1 month of age with associated hyperuremia, hypercreatininemia and hyperparathyroidism.Case report: This baby girl was born by emergency caesarean section for maternal APH at 27+6 weeks. She had an uneventful neonatal period with minimal ventilation. She was treated with ibuprofen, amilorone and frusemide for a PDA with associated heart failure. Her ente...

The aim of the study was to estimate thresholds of android fat mass and android to gynoid fat mass ratio at which metabolic disorders and blood pressure typical of metabolic syndrome appear. Classification and Regression Trees models were used to estimate these thresholds for glucose, HDL cholesterol, triglycerides and systolic and diastolic blood pressure.Methods: healthy postmenopausal women were recruited for the study. Blood samples were collected fo...

Introduction: The thyroglossal duct develops during thyroid gland formation and usually involutes at 7–10 weeks gestation. Its residue can lead to formation of cysts as well as to develop neoplasms within the mass.Case report: A 40-year-old woman was admitted to Department of Otolaryngology because of an enlarging midline neck mass for the last few months, without other worrisome symptoms. A neck ultrasound and CT scan showed a cystic lesion with s...

Introduction: The combination of poly/monostotis fibrous dysplasia, café-au-lait pigmentation of the skin and endocrine hyperfunction (mostly precocious puberty) is known as McCune–Albright syndrome (MAS), a genetic origin syndrome with low incidence. The molecular basis of MAS is a mosaic activating mutation of the α subunit of the G protein (Gsα) gene.We present a clinical case of a 10-year-old boy with partial MAS and GH-secreting ...